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MU Home » The MU Journey » Center for Undergraduate Research and Creativity » Faculty Profiles
Dr. Matt Kesic
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Asssistant Professor of Biology Office: H-230 |
Mailing Address: Methodist University |
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Undergraduate Teaching Areas
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Research Interests I'm currently studying the protease/antiprotease balance in the airway of asthma patients and how this influences susceptibility to a viral infection. My lab utilizes molecular & cellular biology techniques along with a repertoire of newly develop mechanistic viral assays. This work is done in collaboration with UNC Chapel Hill and the US EPA. We are also testing novel therapeutic interventions to limit inflammation and oxidative stress in asthmatic patients. Hobbies
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Publications
Kesic M, Hernandez M, Jaspers I. Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased influenza A virus cleavage and replication letter to the editor: Journal of Allergy and Clinical Immunology (Submitted June 2012)
Kesic M, Myer M, Bauer R, Jaspers I. Exposure to ozone modulates human airway protease/antiprotease balance contributing to increased influenza A infection PLoS One 2012 7(4): e35108. doi:10.1371/journal.pone.0035108
Noah T, Zhou H, Zhang H, Horvath K, Robinette C, Kesic M, Meyer M, Diaz-Sanchez D, Jaspers I. Diesel exhaust exposure and nasal response to attenuated influenza in normal and allergic volunteers American Journal of Respiratory and Critical Care Medicine 2012 185:179-85
Li M, Kannian P, Yin H, Kesic M, Green P. Human T lymphotropic virus type 1 (HTLV-1) regulatory and accessory gene transcript expression and export are not Rex-dependent AIDS Research and Human Retroviruses April 2012, 28(4): 405-410. doi:10.1089/aid.2011.0130.
Wu W, Doreswamy V, Diaz-Sanchez D, Samet J, Kesic M, Dailey L, Zhang W, Jaspers I, Peden D. GSTM1 modulation of IL-8 expression in human bronchial epithelial cells exposed to ozone Free Radical Biology & Medicine 2011 51: 522-529
Kesic M, Simmons S. Bauer R, Jaspers I. Nrf2 expression modifies Influenza A entry and replication in nasal epithelial cells Free Radical Biology & Medicine 2011 51: 444-453
Anupam R, Datta A, Kesic M, Green-Church K, Shkriabai N, Kvaratskhelia M, and Lairmore M.D. Human T-lymphotropic virus type 1 p30 interacts with REG gamma and modulates ataxia telangiectasia mutated to promote cell survival Journal of Biological Chemistry 2011 286:7661-7668
Liu Q, Zhang H, Smeester L, Zou F, Kesic M, Jaspers I, Pi J, Fry R. C. The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel BMC Medical Genomics 2010, 3:37
Kesic M, Doueiri R, Ward M, Semmes O.J, Green P. Phosphorylation regulates human T-cell leukemia virus type 1 Rex function Retrovirology 2009, 6:105
Kesic M, Ward M, Semmes O.J, Green P. Site-specific phosphorylation regulates Human T-cell Leukemia Virus Type-2 Rex function in vivo Journal of Virology 2009 17:83
Xie L*, Kesic M*, Yamamoto B, Li M, Younis I, Lairmore M, and Green P. HTLV-2 Rex carboxyl terminus is an inhibitory/stability domain that regulates Rex functional activity and viral replication Journal of Virology 2009, 10:83 (* indicates equal contributions)
Li M, Kesic M, Yin H, Yu L, Green P. Kinetic analysis of Human T-cell Leukemia Virus Type 1 gene expression in cell culture and infected animals Journal of Virology 2009, 8:83
Book Chapter: Kesic M, Green PL: Retroviral regulatory/accessory genes and cancer. Retroviruses and Insights into Cancer. Dudley J (Ed) Springer Publishing, New York, NY. Pp163-190, 2010.
Yamamoto B, Li M, Kesic M, Younis I, Lairmore M, Green P. Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivo Retrovirology 2008, 5:38
Watkins T, Zelinka L, Kesic M, Ansevin C, Walker G. Identification of skeletal muscle autoantigens by expression library screening using sera from autoimmune rippling muscle disease (ARMD) patients Journal of Cellular Biochemistry 2006 99(1):79-87.
Ph.D. Thesis: Identification and characterization of the post-translational modifications of the HTLV types 1 and 2 regulatory protein Rex June 2009 Matthew J. Kesic
M.S. Thesis: Comparison and Identification of Autoimmune Antigens Present
in Seropositive and Seronegative Myasthenia Gravis May 2004 Matthew J.
Kesic
