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Dr. Matt Kesic

Asssistant Professor of Biology

Office: H-230
Phone: (910) 630-7295
E-Mail:

Mailing Address:

Methodist University
Department of Biology
5400 Ramsey Street
Fayetteville, NC 28311


Education

  • Ph.D. - The Ohio State University (focus in Virology/Immunology)
  • M.S. - Youngstown State University (focus in Molecular Genetics)
  • B.S. - Youngstown State University

Undergraduate Teaching Areas

  • Anatomy and Physiology
  • Clinical Immunology
  • I'm always striving to find new ways to excite students about science and research. I'm a strong believer in engaged learning and hands on approaches to understanding complex physiological pathways.

Research Interests

I'm currently studying the protease/antiprotease balance in the airway of asthma patients and how this influences susceptibility to a viral infection. My lab utilizes molecular & cellular biology techniques along with a repertoire of newly develop mechanistic viral assays. This work is done in collaboration with UNC Chapel Hill and the US EPA. We are also testing novel therapeutic interventions to limit inflammation and oxidative stress in asthmatic patients.

Hobbies

  • Playing piano and guitar
  • Spending time with wife and kids
  • Traveling

Publications

Ghio AJ, Tong H, Soukup JM, Dailey LA, Cheng WY, Samet JM, Kesic MJ, Bromberg PA, Turi JL, Upadhyay D, Budinger GS, Mutlu GM. Sequestration of mitochondrial iron by silica particle initiates a biological effectAm J Physiol Lung Cell Mol Physiol. 2013 Aug 30. [Epub ahead of print]PMID:23997175

Jones SW, Zhou H, Ortiz-Pujols SM, Maile R, Herbst M, Joyner BL Jr, Zhang H, Kesic M, Jaspers I, Short KA, Meyer AA, Peden DB, Cairns BA, Noah TL. Bronchoscopy-derived correlates of lung injury following inhalational injuries: a prospective observational study. PLoS One. 2013 May 17;8(5):e64250. doi: 10.1371/journal.pone.0064250

Meyer M, Kesic MJ, Clarke J, Ho E, Simmen RC, Diaz-Sanchez D, Noah TL, Jaspers I. Sulforaphane induces SLPI secretion in the nasal mucosa. Respir Med. 2013 Mar;107(3):472-5. doi: 10.1016/j.rmed.2012.11.006. Epub 2012 Nov 26.

Kesic M, Hernandez M, Jaspers I. Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased influenza A virus cleavage and replication. Respir Res. 2012 Sep 19;13:82. doi: 10.1186/1465-9921-13-82.

Kesic M, Myer M, Bauer R, Jaspers I. Exposure to ozone modulates human airway protease/antiprotease balance contributing to increased influenza A infection PLoS One 2012 7(4): e35108. doi:10.1371/journal.pone.0035108

Noah T, Zhou H, Zhang H, Horvath K, Robinette C, Kesic M, Meyer M, Diaz-Sanchez D, Jaspers I. Diesel exhaust exposure and nasal response to attenuated influenza in normal and allergic volunteers American Journal of Respiratory and Critical Care Medicine 2012 185:179-85

Li M, Kannian P, Yin H, Kesic M, Green P. Human T lymphotropic virus type 1 (HTLV-1) regulatory and accessory gene transcript expression and export are not Rex-dependent AIDS Research and Human Retroviruses April 2012, 28(4): 405-410. doi:10.1089/aid.2011.0130.

Wu W, Doreswamy V, Diaz-Sanchez D, Samet J, Kesic M, Dailey L, Zhang W, Jaspers I, Peden D. GSTM1 modulation of IL-8 expression in human bronchial epithelial cells exposed to ozone Free Radical Biology & Medicine 2011 51: 522-529

Kesic M, Simmons S. Bauer R, Jaspers I. Nrf2 expression modifies Influenza A entry and replication in nasal epithelial cells Free Radical Biology & Medicine 2011 51: 444-453

Anupam R, Datta A, Kesic M, Green-Church K, Shkriabai N, Kvaratskhelia M, and Lairmore M.D. Human T-lymphotropic virus type 1 p30 interacts with REG gamma and modulates ataxia telangiectasia mutated to promote cell survival Journal of Biological Chemistry 2011 286:7661-7668

Liu Q, Zhang H, Smeester L, Zou F, Kesic M, Jaspers I, Pi J, Fry R. C. The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel BMC Medical Genomics 2010, 3:37

Kesic M, Doueiri R, Ward M, Semmes O.J, Green P. Phosphorylation regulates human T-cell leukemia virus type 1 Rex function Retrovirology 2009, 6:105

Kesic M, Ward M, Semmes O.J, Green P. Site-specific phosphorylation regulates Human T-cell Leukemia Virus Type-2 Rex function in vivo Journal of Virology 2009 17:83

Xie L*, Kesic M*, Yamamoto B, Li M, Younis I, Lairmore M, and Green P. HTLV-2 Rex carboxyl terminus is an inhibitory/stability domain that regulates Rex functional activity and viral replication Journal of Virology 2009, 10:83 (* indicates equal contributions)

Li M, Kesic M, Yin H, Yu L, Green P. Kinetic analysis of Human T-cell Leukemia Virus Type 1 gene expression in cell culture and infected animals Journal of Virology 2009, 8:83

Book Chapter: Kesic M, Green PL: Retroviral regulatory/accessory genes and cancer. Retroviruses and Insights into Cancer. Dudley J (Ed) Springer Publishing, New York, NY. Pp163-190, 2010.

Yamamoto B, Li M, Kesic M, Younis I, Lairmore M, Green P. Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivo Retrovirology 2008, 5:38

Watkins T, Zelinka L, Kesic M, Ansevin C, Walker G. Identification of skeletal muscle autoantigens by expression library screening using sera from autoimmune rippling muscle disease (ARMD) patients Journal of Cellular Biochemistry 2006 99(1):79-87.

Ph.D. Thesis: Identification and characterization of the post-translational modifications of the HTLV types 1 and 2 regulatory protein Rex June 2009 Matthew J. Kesic

M.S. Thesis: Comparison and Identification of Autoimmune Antigens Present in Seropositive and Seronegative Myasthenia Gravis May 2004 Matthew J. Kesic

 

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